Barb and Star Go to Vista Del Mar

By revealing the travel itinerary in the title, Barb and Star Go to Vista Del Mar serves as an advisory to steer clear of its fictional locale.

The motormouthed protagonists of this quirky low-brow comedy might be perfect best friends for one another, but for those not attuned to a specific comic wavelength, their hyperactive shtick would have worked better as a “Saturday Night Live” sketch than at feature length.

Notable for re-teaming Bridesmaids screenwriters Kristen Wiig and Annie Mumolo — who also star in the title roles — this offbeat celebration of sisterhood manages only scattered big laughs amid the labored misfires, and ultimately winds up more obnoxious than endearing.

Barb (Mumolo) and Star (Wiig) are endlessly chipper and self-absorbed best friends who have grown closer since their respective husbands bolted. They share a house and a hairstyle, and work together in a small-town Nebraska furniture store. So when it suddenly closes, they’re crestfallen.

They decide to use their severance to fund a vacation to a Florida beach resort. After gabbing endlessly on the plane ride about how “Trish” is their favorite female name, they manage to find a room in a posh hotel with abundant amenities.

Our middle-aged heroines become smitten with the alluring Edgar (Jamie Dornan), who’s actually a henchman for a vengeful villainess (also played by Wiig) with evil intentions involving mutant mosquitoes. In his clumsy quest to make her boss jealous, Edgar threatens to come between Barb and Star with his desperate romantic advances.

Wiig and Mumolo (Bad Moms) at least deserve kudos for tweaking mainstream expectations and following through on their silly screwball convictions, although most moviegoers will wind up laughing at these yokels rather than with them.

Between endless gags about culottes and “soul douches,” the film never generates any sympathy for these gals, despite their appealing chemistry and happy-go-lucky charisma.

The narrative feature debut of documentary filmmaker Josh Greenbaum (The Short Game) detours into the obligatory hallucinogenic drug sequence, random musical numbers, and bizarre cameos. It needs more monologues by anthropomorphic crabs voiced by Morgan Freeman, and less over-the-top cartoonish mugging.

By the end, you might want to experience Vista Del Mar’s scenic beaches and ample sunshine, only without Barb and Star tagging along. We’ll take a “Wish You Were Here” postcard instead.

Rated PG-13, 107 minutes.